Accept defeat, informally … or what the last words of 19-, 24- and 49-Across do vis-a-vis the first

Quote of the day:
Hope in reality is the worst of all evils because it prolongs the torments of man.
Friedrich Nietzsche

Below is the right or the best answer for Accept defeat, informally … or what the last words of 19-, 24- and 49-Across do vis-a-vis the first :

TAKEANL

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Words of wisdom:
There are even bugs that eat knotweed.
Japanese Proverb

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